2025 NFL OPOY Odds: Jonathan Taylor Separates from Field as Heavy Favorite

Philadelphia's Saquon Barkley's record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.

But that was last season.

Could the Philly star be upended at the conclusion of this NFL campaign?

Let's check out the odds at DraftKings Sportsbook as of Nov. 11, as well as what to know about each leading candidate.

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2025-26 Offensive Player of the Year

Jonathan Taylor, RB, Colts: -350

What to know: Will anyone catch Taylor in this race? At this point, it seems unlikely. His odds have shortened to -350 from -135 over the last week, making him the heavy favorite to win Offensive Player of the Year. The Colts' workhorse running back has helped the team reach their surprising 8-2 record. His 1,139 yards on the ground are a league-best, as are his 15 touchdowns and 189 carries. In his dynamic Week 10 performance, he rushed for 244 yards and three TDs, as Indianapolis defeated the Falcons 31-25 in overtime.

Jaxon Smith-Njigba, WR, Seahawks: +280

What to know: Smith-Njigba leads the NFL in receiving yards with 1,041 for the 7-2 Seahawks. He has six games this season where he racked up at least 100 yards, including 162 yards in a 20-12 win over Jacksonville in Week 6.

Puka Nacua, WR, Rams: +2200

What to know: Nacua has the third-most receptions in the NFL (66) and also has the third-most receiving yards this season (775) despite missing time due to injury.

Christian McCaffrey, RB, 49ers: +2500

What to know: It's business as usual for dual-threat back McCaffrey. He has 180 carries (second), 626 rushing yards and 692 receiving yards for the 6-4 49ers. In San Francisco's Week 10 42-26 loss to the Rams, McCaffrey had only 30 rushing yards, and his OPOY odds dropped to +2500 from +600.

Ja'Marr Chase, WR, Bengals: +4000

What to know: Chase's 76 receptions are best in the NFL and his 831 receiving yards are good for second. In Cincy's Week 9 loss to the Bears, he had eight catches for 111 yards. And keep in mind — he's doing all of this without Joe Burrow.

Bijan Robinson, RB, Falcons: +7500

What to know: Robinson has 679 rushing yards and 467 receiving yards so far this season — a true dual-threat back. However, he hasn't had a 100-yard rushing game or receiving game since Week 6.

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